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KMID : 0359719940120030518
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Journal of the Korean Neurological Association
1994 Volume.12 No. 3 p.518 ~ p.526
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Motor Learning Induces c-fos Expression in Mouse Cerbellum
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Abstract
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Objective. To examine whether cerebellum participates in motor learning and expresses immediate early gene during motor learning.
Background. There are increasing evidences that cerebellum plays a role in otor learning. Motor learning such as skill is one of long term memory that produces structural changes associated with immediate early gene expression.
Methods. We destructed mouse cerebellum surgically and compared the motor performance ith normal control by using Rota-Rods test. Motor performance was tested on repeated trials to measure learning. We also measure the c-fos mRNA level in the
cerebellum
at 0, 30, 60 and 120 minutes of motor learning experiment.
Results. Motor learning is impaired in the mice with cerebellar lesion. C-fos mRNA level increased in the cerebellum at 30 and 60 minutes during motor learning.
Conclusion. Cerebellum participates in motor learning and expresses c-fos gene during motor learning.
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